anti–inflammatory and anti-nociceptive effects of some 2-(2-(2-fluoro phenoxy)-4-cholorophenyl)-n aryline acetohydrazide derivatives
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Synthesis and Evaluation of Anti-acetylcholinesterase Activity of 2-(2-(4-(2-Oxo-2-phenylethyl)piperazin-1-yl) ethyl)Isoindoline-1,3-dione Derivatives with Potential Anti-Alzheimer Effects
Objective(s): Alzheimer's disease (AD) is a neurodegenerative disorder in elderly patients. Decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. Improvement and potentiation of the cholinergic system could be beneficial for treatment of the AD. Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of a...
متن کاملN′-(4-Fluorobenzylidene)-2-(4-fluorophenyl)acetohydrazide
In the title compound, C(15)H(12)F(2)N(2)O, the dihedral angle between the two benzene rings is 48.73 (8)°. The hydrazine group is twisted slightly, with a C-N-N-C torsion angle of 172.48 (12)°. In the crystal, mol-ecules are connected by strong N-H⋯O and weak C-H⋯O hydrogen bonds, forming supra-molecular chains along the c axis. The structure is consolidated by π-π [centroid-centroid separatio...
متن کامل2-(4-Chlorophenoxy)-N′-[2-(4-chlorophenoxy)acetyl]acetohydrazide monohydrate
In the title compound, C(16)H(14)Cl(2)N(2)O(4)·H(2)O, the hydrazine and water mol-ecules are both located on twofold axes. The C-N-N-C torsion angle is -72.66 (1)° and the dihedral angle between the two benzene rings is 67.33 (1)°. In the crystal, mol-ecules are linked into a layer structure by a combination of O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds. Adjacent layers are linked into a three-dimen...
متن کاملN′-[(E)-4-Hydroxybenzylidene]-2-(naphthalen-2-yloxy)acetohydrazide
The asymmetric unit of the title compound, C(19)H(16)N(2)O(3), contains two independent mol-ecules in which the dihedral angles between the naphthalene ring system and the benzene ring are 10.0 (1) and 35.3 (1)°. In the crystal, mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds, forming a two-dimensional framework parallel to (001). Weak C-H⋯O and C-H⋯N hydrogen bonds complete a three-dim...
متن کامل2-[2-(2,6-Dichloroanilino)phenyl]-N′-(4-propylcyclohexylidene)acetohydrazide
The asymmetric unit of the title compound, C(23)H(27)Cl(2)N(3)O, contains two crystallographically independent mol-ecules in which the dihedral angles between the benzene rings are 70.1 (3) and 63.8 (3)°. In each mol-ecule an intra-molecular N-H⋯O hydrogen bond generates an S(7) ring. The atoms of the propyl grouping of one mol-ecule are disordered over two orientations with occupancies of 0.66...
متن کاملN′-(2-Fluorobenzylidene)acetohydrazide
The title compound, C(9)H(9)FN(2)O, was prepared by the reaction between 2-fluoro-benzophenone and acetohydrazide. In the crystal structure, inversion dimers linked by pairs of N-H⋯O hydrogen bonds occur, generating R(2) (2)(8) loops.
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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